ΪʲôһЩ֢ͻȻˣ

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2018-10-27

2016622/BIOON/--һЩ֢ʧȷʵ

һǧо¼˾Ȼ˵İ֢

Ϊʲôᷢпһð֢¼֢Ȼ˵IJ13

ʥͽPeregrineLaziosiĹһصϸȾ֮Էʧ

19ĩҽ-WilliamColey۲쵽յпܹ һϸ磨磩ܹĺܶಡڵС

֪ûнκΰƵԷʧͨڸȾϸԭ棩֮

ζż򵥵ؼϵͳᵼڹȥ70ȻڶͰ֢бرǺɫһƤϸһĸϸneuroblastomaһЩ͵Ѫ

ȻܴЩ˵ʷ¼Ȼ֪Ļ ںܶಡܿܲûоб

ôȻ˵һֿܵԭ崥ϸչʾԿԭ߷Ӧ ֹ֧۵֤ǹ۲쵽һЩƤԺɫڲڹϸ һ˹עIJһͨгIJᵼʣಿȻ ۻľֲ߷Ӧֹʣಿ

ŴΪϴڷdzı仯ᵼһЩ˳طҲᵼһЩ˷Ȼ ͬ͵ٰܹԲͬķʽͻ ܹӰɢͬλĿζӦ пܵͻҲȻ

һֺĶ֢ͯṩһЩĸϸһֺ͵Ķ֢ͯпܽʾ仯οӰȻ ӢÿԼ100ͯϻּڶּͯչ÷dzͬ 18µĸϸͯڽܻûнκʱܹʧ1

18ϵĸϸͯҪǿֻ4050%Ĵʣ2 о2ĸϸ1ĸϸнȻͬŴ ͵ͨиˮƽϸTrkAܹϸɱ

֮2ĸϸиˮƽһֲͬTrKBʹӾϮ

һֿܵĽ;2ĸϸ1ĸϸֳdz͵Ķζø øضDNAƬΣijܹϸط

1ĸϸڽϵ͵ĶøDNAƬηdzDzȶӶϸ Ŵ仯Ҳܹų

Ŵ仯ӰϸDNAͨDNAּͬϻѧǣ׻ıֵ׵Ļ ͬDNAеǾвͬѧǵϸȫͬΪһЩҴݻ оѱ2ĸϸ1ĸϸĻѧǴIJͬЩֻdzķ

Ȼ˵ľȷȻDzȷǺܿܵھijЩŴǿ߷Ӧ϶ش һŴ봥߷Ӧ֮ĹоܹȻṩ һǸŴܹΪشϵͳԵذ򹥻ҩ

ģȻ˵ĶģͽʵһĿһֱĹ

ȣϵԭӭת

Ѷ.ԭʼοϣ[1].SaintPeregrine,--thepatronsaintofcancerpatientsPMC:[2].ColeysLessonsRemembered:AugmentingMistletoeTherapydoi:[3].Spontaneousregressionofmetastasesfrommelanoma:reviewoftheliteraturedoi:[4].Spontaneousregressionofthoracicmalignanciesdoi:[5].Mechanismsofneuroblastomaregressiondoi:[6].SpontaneousregressionofchroniclymphocyticleukemiatoamonoclonalB-lymphocytosisortoanormalphenotypedoi:[7].Melanomaasamodeltumourforimmuno-oncologydoi:[8].AcaseofspontaneousdisappearanceofpulmonarymetastasisofrenalcellcarcinomafollowingnephrectomyPMC:[9].ChildhoodcancersurvivalinEurope1999-2007:resultsofEUROCARE-5--apopulation-basedstudydoi:[10].Neuroblastomaepigenetics:fromcandidategeneapproachestogenome-widescreeningsdoi:[11].HistonechaperoneCHAF1Ainhibitsdifferentiationandpromotesaggressiveneuroblastomadoi: